A case-control study for the efficacy of oral zinc in the prevention and mitigation of COVID-19

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Front Med (Lausanne). Dec 13, 2021; 8: 756707. doi: 10.3389 / fmed.2021.756707. Electronic collection 2021.


Fund: The current coronavirus disease-19 (COVID-19) pandemic (caused by infection with Severe Acute Respiratory Syndrome (SARS) -coronavirus (CoV-2)) has placed a burden on the medical community and society in its together. Efforts to reduce disease burden and mortality during the pandemic have focused on research to rapidly determine age-stratified seroepidemiologic surveys, a centralized research agenda to accelerate rapid diagnoses and the most promising serologic tests , and testing of potential antiviral agents, immunologic therapies and vaccine candidates.Despite the lack of official recognition of the role of nutrition in combating COVID-19 infection, several groups have proposed zinc supplementation as an adjuvant for support for participants. Method: In an outpatient, interventional, prospective, single-blind study, we evaluated the effectiveness of zinc supplementation in the prevention and mitigation of COVID-19 in two groups of similar participants. In Clinic A (m = 104) participants were randomized to receive 10 mg, 25 mg or 50 mg of zinc picolinate per day, and control participants from Clinic B were matched based on their demographic characteristics and clinical parameters (m = 96). All participants were compared on the basis of demographics, clinical comorbidities, blood count, kidney function, vitamin D levels, and their development of symptomatic COVID-19 infection. Results: Symptomatic COVID-19 infection was significantly higher among participants in the control group (NOT = 9, 10.4%) than treatment participants (NOT = 2, 1.9%), p = 0.015. Unadjusted odds ratio says symptomatic COVID-19 infection was 5.93 [95% CI: 1.51, 39.26] higher in the control group, p p p = 0.01). Discussion: The results of our study suggest that zinc supplementation in all three doses (10, 25, and 50 mg) may be an effective prophylaxis for symptomatic COVID-19 and may lessen the severity of COVID-19 infection. Conclusion: Zinc is a relatively inexpensive mineral nutrient that is an effective prophylactic agent in preventing and alleviating the potentially fatal symptomatic infection of SARS-CoV-2. As the COVID-19 pandemic continues with a delay in vaccinations in some areas and the emergence of dangerously infectious variants of SARS-CoV-2 continues, it is important to replicate our data in other populations and locations and engage public health and nutrition services. on the emerging need to use zinc supplanting or fortification of staple foods in preventing and mitigating the severity of COVID-19 infection.

PMID:34966750 | PMC:PMC8711630 | DO I:10.3389 / fmed.2021.756707

Sara H. Byrd