Daily antihypertensive schedule does not affect efficacy
FRIDAY, Sept. 16, 2022 (HealthDay News) — According to late-breaking research presented at the European Society of Cardiology Congress 2022, held Aug. 26-29 in Barcelona, Spain.
Thomas MacDonald, from the University of Dundee in the UK, and his colleagues randomly assigned 21,104 patients with high blood pressure (1:1) to take their usual blood pressure medication in the morning or evening. The median follow-up was 5.2 years.
The researchers found that the composite primary endpoint of hospitalization for nonfatal myocardial infarction or nonfatal stroke or vascular death occurred in 3.4% of participants in the evening dosing group (0.69 events per 100 patient-years) and 3.7% of patients in the morning dosing group. group (0.72 events per 100 patient-years), giving an unadjusted hazard ratio of 0.95 (95% confidence interval, 0.83 to 1.10; P = 0.53). The results were similar in the analyzes of predefined subgroups.
“People with high blood pressure should take their regular antihypertensive medications at a time of day that is convenient for them and minimizes adverse effects,” MacDonald said in a statement.
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