Study Shows Effectiveness of Juvenescence’s Ketosis-Inducing Supplement

A recent study published in the Journal of the American Nutrition Association​ demonstrates the effectiveness of the company’s proprietary C6 Ketone Di-ester – also known as Bis-hexanoyl (R)-1,3-butanediol​ (BH-BD) — in the induction of ketosis.

“Here, we provide the first description of the kinetics of ketones and blood metabolites up to five hours after consumption of a BH-BD-containing beverage by resting healthy adults under three randomized crossover conditions,”​ said the authors of the study, which was funded by BHB Therapeutics, a partnership between Juvenescence and The Buck Institute for Research on Aging.

The conditions tested on a group of eight healthy subjects were 25 g of BH-BD taken with a meal, 25 g taken on an empty stomach and 12.5 g taken with a meal. In all cases, there was an increase in beta-hydroxybutyrate (BHB), a ketone made by the body that provides energy and burns fat during fasting states or through low carbohydrate diets and high in fat, i.e. the ketogenic diet.

The results also demonstrated a decrease in circulating concentrations of metabolites such as glucose and free fatty acids, as well as an increase in insulin when BH-BD was consumed with a meal.

Ketosis in minutes

In recent years, synthetically delivered exogenous ketones in supplement form have emerged as an easier and faster route to inducing a state of ketosis than more restrictive conventional methods.

“Until the development of exogenous ketones, it would take days of strict dieting or fasting days without food to increase ketones,” ​Martin Ducker, Scientific Director of Juvenescence Life, told NutraIngredients-USA.

“And there was no way to increase ketones in the presence of even modest amounts of dietary carbohydrates. Now, ingredients like this ketone ester allow us to increase blood ketone levels within minutes, which which allows us to use ketones in a targeted way that we hope will unlock multiple functional benefits,” he added.

A metabolic switch for healthy aging

BH-BD is the main active ingredient in Juvenescence’s Metabolic Switch supplement which was launched in 2021 with the tagline “Reinvent a life“.

Potential benefits cited include sustained energy, promoting lean muscle, supporting healthy blood sugar levels, mental focus and immune function, and ultimately increasing longevity through a healthy and flexible metabolism.

Now that we have demonstrated the ingredient’s effectiveness in increasing blood ketone concentrations, we can begin to examine how it modulates different clinical and functional parameters relevant to healthy aging,” Ducker said.

There are many areas where ketones have shown promise, including physical and cognitive function as well as general metabolic health. We are currently evaluating options to decide which areas to prioritize.

Metabolic Switch is sold online in unflavored powder and a 2.5 fl. oz. Nitro chocolate drink, with every 1.25 fl. oz. portion containing 25g of BH-BD. Previous trials have demonstrated the tolerability of the ketone ester, which has received GRAS (Generally Recognized as Safe) status from the FDA.

Source: Journal of the American Nutrition Association
2022, doi: 10.1080/07315724.2021.2015476​
“Bis hexanoyl (R)-1,3-butanediol, a novel ketogenic ester, acutely increases circulating levels of r- and s-ß-hydroxybutyrate in healthy adults”
Authors: Christopher D. Crabtree, and. Al.

Sara H. Byrd